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SYDE1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q6ZW31
Clone Names 100422203
Peptide ID 100422203
Additional Information
Other Names Rho GTPase-activating protein SYDE1, Synapse defective protein 1 homolog 1, Protein syd-1 homolog 1, SYDE1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYDE1
Function GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469).
Tissue Location Expressed in trophoblast cells of placental villi. EMBL; AK023573; BAB14612.1; -; mRNA EMBL; AK123686; BAC85676.1; -; mRNA EMBL; CH471106; EAW84462.1; -; Genomic_DNA EMBL; CH471106; EAW84463.1; -; Genomic_DNA EMBL; BC018942; AAH18942.2; -; mRNA EMBL; BC029926; AAH29926.1; -; mRNA CCDS; CCDS12324.1; -. [Q6ZW31-1] CCDS; CCDS74299.1; -. [Q6ZW31-2] RefSeq; NP_001287839.1; NM_001300910.1. [Q6ZW31-2] RefSeq; NP_149014.3; NM_033025.5. [Q6ZW31-1] UniGene; Hs.528701; - UniGene; Hs.706845; - ProteinModelPortal; Q6ZW31; - BioGrid; 124489; 64 IntAct; Q6ZW31; 55 STRING; 9606.ENSP00000341489; - iPTMnet; Q6ZW31; - PhosphoSitePlus; Q6ZW31; - BioMuta; SYDE1; - DMDM; 74723056; - EPD; Q6ZW31; - MaxQB; Q6ZW31; - PaxDb; Q6ZW31; - PeptideAtlas; Q6ZW31; - PRIDE; Q6ZW31; - ProteomicsDB; 68453; - ProteomicsDB; 68454; -. [Q6ZW31-2] DNASU; 85360; - Ensembl; ENST00000342784; ENSP00000341489; ENSG00000105137. [Q6ZW31-1] Ensembl; ENST00000600440; ENSP00000470733; ENSG00000105137. [Q6ZW31-2] GeneID; 85360; - KEGG; hsa:85360; - UCSC; uc002nah.2; human. [Q6ZW31-1] CTD; 85360; - EuPathDB; HostDB:ENSG00000105137.12; - GeneCards; SYDE1; - H-InvDB; HIX0014846; - HGNC; HGNC:25824; SYDE1 HPA; HPA013328; - MIM; 617377; gene neXtProt; NX_Q6ZW31; - OpenTargets; ENSG00000105137; - PharmGKB; PA142670851; - eggNOG; KOG1452; Eukaryota eggNOG; ENOG410XYAD; LUCA GeneTree; ENSGT00920000148945; - HOGENOM; HOG000154469; - HOVERGEN; HBG053037; - InParanoid; Q6ZW31; - KO; K20655; - OMA; DHTFHLE; - OrthoDB; EOG091G01HK; - PhylomeDB; Q6ZW31; - TreeFam; TF323458; - Reactome; R-HSA-194840; Rho GTPase cycle GenomeRNAi; 85360; - PRO; PR:Q6ZW31; - Proteomes; UP000005640; Chromosome 19 Bgee; ENSG00000105137; - CleanEx; HS_SYDE1; - ExpressionAtlas; Q6ZW31; baseline and differential Genevisible; Q6ZW31; HS GO; GO:0005737; C:cytoplasm; IBA:GO_Central GO; GO:0005829; C:cytosol; TAS:Reactome GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB GO; GO:0090630; P:activation of GTPase activity; ISS:UniProtKB GO; GO:1901165; P:positive regulation of trophoblast cell migration; IMP:UniProtKB GO; GO:0051493; P:regulation of cytoskeleton organization; IMP:UniProtKB GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome GO; GO:0007165; P:signal transduction; IEA:InterPro Gene3D; 1.10.555.10; -; 1 InterPro; IPR008936; Rho_GTPase_activation_prot InterPro; IPR000198; RhoGAP_dom Pfam; PF00620; RhoGAP; 1 SMART; SM00324; RhoGAP; 1 SUPFAM; SSF48350; SSF48350; 1 PROSITE; PS50238; RHOGAP; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome CHAIN 1 735 Rho GTPase-activating protein SYDE1 /FTId=PRO_0000312158 DOMAIN 398 604 Rho-GAP. {ECO:0000255|PROSITE- ProRule:PRU00172} COMPBIAS 32 162 Pro-rich MOD_RES 224 224 Phosphoserine MOD_RES 231 231 Phosphoserine MOD_RES 235 235 Phosphoserine MOD_RES 244 244 Phosphoserine MOD_RES 575 575 Phosphoserine MOD_RES 681 681 Phosphoserine {ECO:0000250|UniProtKB:Q9DBZ9} MOD_RES 683 683 Phosphoserine VAR_SEQ 30 96 Missing (in isoform 2) /FTId=VSP_029717 VARIANT 408 408 R -> Q (in a pancreatic ductal adenocarcinoma sample; somatic mutation; dbSNP:rs772906202) /FTId=VAR_062661 SEQUENCE 735 AA; 79793 MW; 87310623E756EB31 CRC64; MAEPLLRKTF SRLRGREKLP RKKSDAKERG HPAQRPEPSP PEPEPQAPEG SQAGAEGPSS PEASRSPARG AYLQSLEPSS RRWVLGGAKP AEDTSLGPGV PGTGEPAGEI WYNPIPEEDP RPPAPEPPGP QPGSAESEGL APQGAAPASP PTKASRTKSP GPARRLSIKM KKLPELRRRL SLRGPRAGRE RERAAPAGSV ISRYHLDSSV GGPGPAAGPG GTRSPRAGYL SDGDSPERPA GPPSPTSFRP YEVGPAARAP PAALWGRLSL HLYGLGGLRP APGATPRDLC CLLQVDGEAR ARTGPLRGGP DFLRLDHTFH LELEAARLLR ALVLAWDPGV RRHRPCAQGT VLLPTVFRGC QAQQLAVRLE PQGLLYAKLT LSEQQEAPAT AEPRVFGLPL PLLVERERPP GQVPLIIQKC VGQIERRGLR VVGLYRLCGS AAVKKELRDA FERDSAAVCL SEDLYPDINV ITGILKDYLR ELPTPLITQP LYKVVLEAMA RDPPNRVPPT TEGTRGLLSC LPDVERATLT LLLDHLRLVS SFHAYNRMTP QNLAVCFGPV LLPARQAPTR PRARSSGPGL ASAVDFKHHI EVLHYLLQSW PDPRLPRQSP DVAPYLRPKR QPPLHLPLAD PEVVTRPRGR GGPESPPSNR YAGDWSVCGR DFLPCGRDFL SGPDYDHVTG SDSEDEDEEV GEPRVTGDFE DDFDAPFNPH LNLKDFDALI LDLERELSKQ INVCL
Research Areas
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GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity).


Ota, T., et al. Nat. Genet. 36(1):40-45(2004)

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Cat# BP16549a
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