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LGI2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N0V4
Clone Names 100603066
Additional Information
Gene ID 55203
Other Names Leucine-rich repeat LGI family member 2, LGI1-like protein 2, Leucine-rich glioma-inactivated protein 2, LGI2, KIAA1916, LGIL2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LGI2
Synonyms KIAA1916, LGIL2
Function Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells.
Cellular Location Secreted.
Tissue Location Brain, heart and placenta.
Research Areas
Citations (0)
citation

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Background

The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic ?/? horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LGI2 (leucine-rich repeat LGI family, member 2), also known as KIAA1916 or LGIL2, is a 545 amino acid secreted protein that contains four LRR repeats and seven EAR repeats. Expressed in heart, brain and placenta, LGI2 shares high sequence similarity with other LGI family members and is thought to play a role in the pathogenesis of epileptic disorders.

References

Limviphuvadh, V., et al. J Bioinform Comput Biol 8(1):117-127(2010)Gu, W., et al. Mol. Biol. Evol. 22(11):2209-2216(2005)Wang, L., et al. J. Mol. Med. 83(10):812-821(2005)Staub, E., et al. Trends Biochem. Sci. 27(9):441-444(2002)Scheel, H., et al. Hum. Mol. Genet. 11(15):1757-1762(2002)

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$ 277.78
Cat# BP16550c
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