|Other Names||Leucine-rich repeat LGI family member 2, LGI1-like protein 2, Leucine-rich glioma-inactivated protein 2, LGI2, KIAA1916, LGIL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Brain, heart and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic ?/? horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LGI2 (leucine-rich repeat LGI family, member 2), also known as KIAA1916 or LGIL2, is a 545 amino acid secreted protein that contains four LRR repeats and seven EAR repeats. Expressed in heart, brain and placenta, LGI2 shares high sequence similarity with other LGI family members and is thought to play a role in the pathogenesis of epileptic disorders.
Limviphuvadh, V., et al. J Bioinform Comput Biol 8(1):117-127(2010)Gu, W., et al. Mol. Biol. Evol. 22(11):2209-2216(2005)Wang, L., et al. J. Mol. Med. 83(10):812-821(2005)Staub, E., et al. Trends Biochem. Sci. 27(9):441-444(2002)Scheel, H., et al. Hum. Mol. Genet. 11(15):1757-1762(2002)
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