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AUP1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y679
Clone Names 100603082
Additional Information
Gene ID 550
Other Names Ancient ubiquitous protein 1, AUP1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AUP1 (HGNC:891)
Function Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (PubMed:18711132, PubMed:21857022). Plays a role in lipid droplet formation (PubMed:21857022). Induces lipid droplet clustering (PubMed:24039768). Recruits ubiquitin- conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed:23223569, PubMed:21127063). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (PubMed:23223569). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (PubMed:28183703).
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet
Tissue Location Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain
Research Areas
Citations (0)
citation

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Background

This gene encodes a protein that contains a domain withhomology to the ancient conserved region of the archain 1 gene anda domain that may be involved in binding ubiquitin-conjugatingenzymes. The protein encoded by this gene has been shown to bind tothe conserved membrane-proximal sequence of the cytoplasmic tail ofintegrin alpha(IIb) subunits. These subunits play a crucial role inthe integrin alpha(IIb)beta(3) inside-out signalling in plateletsand megakaryocytes that leads to platelet aggregation and thrombusformation. This gene overlaps the gene for mitochondrial serineprotease 25.

References

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Kato, A., et al. J. Biol. Chem. 277(32):28934-28941(2002)Karpisheva, K.V., et al. Tsitologiia 44(9):846-851(2002)Karpisheva, K.V., et al. Tsitologiia 44(9):839-845(2002)Jang, W., et al. Genomics 36(2):366-368(1996)

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$ 277.78
Cat# BP16554b
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