|Other Names||Ancient ubiquitous protein 1, AUP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side|
|Tissue Location||Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains a domain withhomology to the ancient conserved region of the archain 1 gene anda domain that may be involved in binding ubiquitin-conjugatingenzymes. The protein encoded by this gene has been shown to bind tothe conserved membrane-proximal sequence of the cytoplasmic tail ofintegrin alpha(IIb) subunits. These subunits play a crucial role inthe integrin alpha(IIb)beta(3) inside-out signalling in plateletsand megakaryocytes that leads to platelet aggregation and thrombusformation. This gene overlaps the gene for mitochondrial serineprotease 25.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Kato, A., et al. J. Biol. Chem. 277(32):28934-28941(2002)Karpisheva, K.V., et al. Tsitologiia 44(9):846-851(2002)Karpisheva, K.V., et al. Tsitologiia 44(9):839-845(2002)Jang, W., et al. Genomics 36(2):366-368(1996)
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