EDEM3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BZQ6 |
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Clone Names | 100603100 |
Gene ID | 80267 |
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Other Names | ER degradation-enhancing alpha-mannosidase-like protein 3, Alpha-1, 2-mannosidase EDEM3, EDEM3, C1orf22 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | EDEM3 |
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Synonyms | C1orf22 |
Function | Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans (PubMed:25092655). May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952). May have alpha 1,2-mannosidase activity (By similarity). |
Cellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE- ProRule:PRU10138} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Quality control in the endoplasmic reticulum (ER) ensuresthat only properly folded proteins are retained in the cell throughrecognition and degradation of misfolded or unassembled proteins.EDEM3 belongs to a group of proteins that accelerate degradation ofmisfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed16431915]).
References
Hirao, K., et al. J. Biol. Chem. 281(14):9650-9658(2006)Mast, S.W., et al. Glycobiology 15(4):421-436(2005)Olivari, S., et al. J. Biol. Chem. 280(4):2424-2428(2005)Sood, R., et al. Genomics 73(2):211-222(2001)
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