DEF6 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H4E7 |
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Clone Names | 100603109 |
Gene ID | 50619 |
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Other Names | Differentially expressed in FDCP 6 homolog, DEF-6, IRF4-binding protein, DEF6, IBP |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DEF6 |
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Synonyms | IBP |
Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). |
Cellular Location | Cytoplasm. Cell membrane Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate (PubMed:15023524). Binds to actin filaments (PubMed:15023524) |
Tissue Location | Broadly expressed in the immune system. Highly expressed in T cells (PubMed:31308374). |
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Provided below are standard protocols that you may find useful for product applications.
Background
DEF6, or IBP, is a guanine nucleotide exchange factor(GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highlyexpressed in B and T cells (Gupta et al., 2003 [PubMed12923183]).
References
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Zhang, Z., et al. Cancer Epidemiol 33(2):130-136(2009)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)
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