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DEF6 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H4E7
Clone Names 100603109
Peptide ID 100603109
Additional Information
Gene ID 50619
Other Names Differentially expressed in FDCP 6 homolog, DEF-6, IRF4-binding protein, DEF6, IBP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DEF6
Synonyms IBP
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).
Cellular Location Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate (PubMed:15023524). Binds to actin filaments (PubMed:15023524)
Tissue Location Broadly expressed in the immune system and can be detected in T and B-cells.
Research Areas
Citations (0)

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Background

DEF6, or IBP, is a guanine nucleotide exchange factor(GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highlyexpressed in B and T cells (Gupta et al., 2003 [PubMed12923183]).

References

Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Zhang, Z., et al. Cancer Epidemiol 33(2):130-136(2009)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)

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$ 80.00
Cat# BP16557b
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