|Other Names||Differentially expressed in FDCP 6 homolog, DEF-6, IRF4-binding protein, DEF6, IBP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate (PubMed:15023524). Binds to actin filaments (PubMed:15023524)|
|Tissue Location||Broadly expressed in the immune system and can be detected in T and B-cells.|
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Provided below are standard protocols that you may find useful for product applications.
DEF6, or IBP, is a guanine nucleotide exchange factor(GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highlyexpressed in B and T cells (Gupta et al., 2003 [PubMed12923183]).
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Zhang, Z., et al. Cancer Epidemiol 33(2):130-136(2009)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)
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