|Other Names||SLIT and NTRK-like protein 2, SLITRK2, CXorf2, KIAA1854, SLITL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CXorf2, KIAA1854, SLITL1|
|Function||It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses neurite outgrowth (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Cell membrane|
|Tissue Location||Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an integral membrane protein thatcontains two N-terminal leucine-rich repeats domains and containsC-terminal regions similar to neurotrophin receptors. The encodedprotein may play a role in modulating neurite activity.Alternatively spliced transcript variants encoding the same proteinhave been described.
Piton, A., et al. Mol. Psychiatry (2010) In press :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Smith, E.N., et al. Mol. Psychiatry 14(8):755-763(2009)Aruga, J., et al. Gene 315, 87-94 (2003) :
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