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DPH1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BZG8
Clone Names 100603138
Peptide ID 100603138
Additional Information
Gene ID 1801
Other Names Diphthamide biosynthesis protein 1, DPH1 homolog, HsDph1, Diphthamide biosynthesis protein 2 homolog-like 1, DPH-like 1, DPH2-like 1, Diphthamide biosynthesis protein 2-like, Ovarian cancer-associated gene 1 protein, DPH1, DPH2L, DPH2L1, OVCA1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DPH1
Synonyms DPH2L, DPH2L1, OVCA1
Function Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity).
Cellular Location Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization
Tissue Location Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors
Research Areas
Citations (0)

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Diphthamide is a unique posttranslationally modifiedhistidine found only in translation elongation factor-2 (EEF2; MIM130610). This modification is conserved from archaebacteria tohumans and serves as the target for ADP-ribosylation andinactivation of EEF2 by diphtheria toxin (DT) and Pseudomonasexotoxin A. DPH1 is 1 of several enzymes involved in synthesis ofdiphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[suppliedby OMIM].


Liu, S., et al. Mol. Cell. Biol. 24(21):9487-9497(2004)Cardoso, C., et al. Am. J. Hum. Genet. 72(4):918-930(2003)Chen, C.M., et al. Biochem. Biophys. Res. Commun. 286(5):1019-1026(2001)Salicioni, A.M., et al. Genomics 69(1):54-62(2000)Bruening, W., et al. Cancer Res. 59(19):4973-4983(1999)

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$ 80.00
Cat# BP16559b
Availability: In Stock
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