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DPH1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BZG8 |
|---|---|
| Clone Names | 100603138 |
| Gene ID | 1801 |
|---|---|
| Other Names | Diphthamide biosynthesis protein 1, DPH1 homolog, HsDph1, Diphthamide biosynthesis protein 2 homolog-like 1, DPH-like 1, DPH2-like 1, Diphthamide biosynthesis protein 2-like, Ovarian cancer-associated gene 1 protein, DPH1, DPH2L, DPH2L1, OVCA1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DPH1 {ECO:0000303|PubMed:26220823} |
|---|---|
| Function | Catalyzes the first step of diphthamide biosynthesis, a post- translational modification of histidine which occurs in elongation factor 2 (PubMed:30877278). DPH1 and DPH2 transfer a 3-amino-3- carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Acts as a tumor suppressor (PubMed:10519411). |
| Cellular Location | Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization. |
| Tissue Location | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Diphthamide is a unique posttranslationally modifiedhistidine found only in translation elongation factor-2 (EEF2; MIM130610). This modification is conserved from archaebacteria tohumans and serves as the target for ADP-ribosylation andinactivation of EEF2 by diphtheria toxin (DT) and Pseudomonasexotoxin A. DPH1 is 1 of several enzymes involved in synthesis ofdiphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[suppliedby OMIM].
References
Liu, S., et al. Mol. Cell. Biol. 24(21):9487-9497(2004)Cardoso, C., et al. Am. J. Hum. Genet. 72(4):918-930(2003)Chen, C.M., et al. Biochem. Biophys. Res. Commun. 286(5):1019-1026(2001)Salicioni, A.M., et al. Genomics 69(1):54-62(2000)Bruening, W., et al. Cancer Res. 59(19):4973-4983(1999)
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