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DNMT3L Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UJW3
Clone Names 110728006
Peptide ID 110728006
Additional Information
Gene ID 29947
Other Names DNA (cytosine-5)-methyltransferase 3-like, DNMT3L
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
Cellular Location Nucleus.
Tissue Location Expressed at low levels in several tissues including testis, ovary, and thymus
Research Areas
Citations (0)

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CpG methylation is an epigenetic modification that isimportant for embryonic development, imprinting, and X-chromosomeinactivation. Studies in mice have demonstrated that DNAmethylation is required for mammalian development. This geneencodes a nuclear protein with similarity to DNAmethyltransferases. This protein is not thought to function as aDNA methyltransferase as it does not contain the amino acidresidues necessary for methyltransferase activity. However, thisprotein does stimulate de novo methylation by DNA cytosinemethyltransferase 3 alpha and it is thought to be required for theestablishment of maternal genomic imprints. This protein alsomediates transcriptional repression through interaction withhistone deacetylase 1. Alternative splicing results in twotranscript variants. An additional splice variant has beendescribed but its biological validity has not been determined.


Holz-Schietinger, C., et al. J. Biol. Chem. 285(38):29091-29100(2010)Manderwad, G.P., et al. Arch. Pathol. Lab. Med. 134(8):1193-1196(2010)Kim, H., et al. Int. J. Oncol. 36(6):1563-1572(2010)Minami, K., et al. Clin. Cancer Res. 16(10):2751-2759(2010)Haggarty, P., et al. PLoS ONE 5 (6), E11329 (2010) :

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$ 80.00
Cat# BP16566b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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