|Other Names||DNA (cytosine-5)-methyltransferase 3-like, DNMT3L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.|
|Tissue Location||Expressed at low levels in several tissues including testis, ovary, and thymus|
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CpG methylation is an epigenetic modification that isimportant for embryonic development, imprinting, and X-chromosomeinactivation. Studies in mice have demonstrated that DNAmethylation is required for mammalian development. This geneencodes a nuclear protein with similarity to DNAmethyltransferases. This protein is not thought to function as aDNA methyltransferase as it does not contain the amino acidresidues necessary for methyltransferase activity. However, thisprotein does stimulate de novo methylation by DNA cytosinemethyltransferase 3 alpha and it is thought to be required for theestablishment of maternal genomic imprints. This protein alsomediates transcriptional repression through interaction withhistone deacetylase 1. Alternative splicing results in twotranscript variants. An additional splice variant has beendescribed but its biological validity has not been determined.
Holz-Schietinger, C., et al. J. Biol. Chem. 285(38):29091-29100(2010)Manderwad, G.P., et al. Arch. Pathol. Lab. Med. 134(8):1193-1196(2010)Kim, H., et al. Int. J. Oncol. 36(6):1563-1572(2010)Minami, K., et al. Clin. Cancer Res. 16(10):2751-2759(2010)Haggarty, P., et al. PLoS ONE 5 (6), E11329 (2010) :
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