|Other Names||Prokineticin-2, PK2, Protein Bv8 homolog, PROK2, BV8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.|
|Tissue Location||Expressed in the testis and, at low levels, in the small intestine|
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This gene encodes a protein expressed in thesuprachiasmatic nucleus (SCN) circadian clock that may function asthe output component of the circadian clock. The secreted form ofthe encoded protein may also serve as a chemoattractant forneuronal precursor cells in the olfactory bulb. Proteins from othervertebrates which are similar to this gene product were isolatedbased on homology to snake venom and secretions from frog skin, andhave been shown to have diverse functions. Mutations in this geneare associated with Kallmann syndrome 4. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Catalano, R.D., et al. Mol. Hum. Reprod. 16(5):311-319(2010)Sarfati, J., et al. J. Clin. Endocrinol. Metab. 95(2):659-669(2010)Zhong, C., et al. Clin. Cancer Res. 15(8):2675-2684(2009)Canto, P., et al. J. Androl. 30(1):41-45(2009)Abreu, A.P., et al. J. Clin. Endocrinol. Metab. 93(10):4113-4118(2008)
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