TTL Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NG68 |
---|---|
Clone Names | 100406198 |
Gene ID | 150465 |
---|---|
Other Names | Tubulin--tyrosine ligase, TTL, TTL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TTL |
---|---|
Function | Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
TTL is a cytosolic enzyme involved in theposttranslational modification of alpha-tubulin (see MIM 602529).Alpha-tubulin within assembled microtubules is detyrosinated overtime at the C terminus. After microtubule disassembly, TTL restoresthe tyrosine residues and consequently participates in a cycle oftubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed14571137]).
References
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :Erck, C., et al. Cytogenet. Genome Res. 101(1):47-53(2003)Mialhe, A., et al. Cancer Res. 61(13):5024-5027(2001)Ersfeld, K., et al. J. Cell Biol. 120(3):725-732(1993)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.