|Other Names||Tubulin--tyrosine ligase, TTL, TTL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.|
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Provided below are standard protocols that you may find useful for product applications.
TTL is a cytosolic enzyme involved in theposttranslational modification of alpha-tubulin (see MIM 602529).Alpha-tubulin within assembled microtubules is detyrosinated overtime at the C terminus. After microtubule disassembly, TTL restoresthe tyrosine residues and consequently participates in a cycle oftubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed14571137]).
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :Erck, C., et al. Cytogenet. Genome Res. 101(1):47-53(2003)Mialhe, A., et al. Cancer Res. 61(13):5024-5027(2001)Ersfeld, K., et al. J. Cell Biol. 120(3):725-732(1993)
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