SEL1L Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UBV2 |
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Clone Names | 100318056 |
Gene ID | 6400 |
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Other Names | Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L, SEL1L, TSA305 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SEL1L |
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Synonyms | TSA305 |
Function | Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
Tissue Location | Highly expressed in pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SEL1L may play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.
References
Ban, H.J., et al. BMC Genet. 11, 26 (2010) :Riemer, J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(35):14831-14836(2009)Cormier, J.H., et al. Mol. Cell 34(5):627-633(2009)Oresic, K., et al. Biosci. Rep. 29(3):173-181(2009)Cattaneo, M., et al. J. Biol. Chem. 284(17):11405-11415(2009)
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