|Other Names||Wiskott-Aldrich syndrome protein family member 3, WASP family protein member 3, Protein WAVE-3, Verprolin homology domain-containing protein 3, WASF3, KIAA0900, SCAR3, WAVE3|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0900, SCAR3, WAVE3|
|Function||Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Expressed in ovary and brain.|
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This gene encodes a member of the Wiskott-Aldrich syndromeprotein family. The gene product is a protein that forms amultiprotein complex that links receptor kinases and actin. Bindingto actin occurs through a C-terminal verprolin homology domain inall family members. The multiprotein complex serves to tranducesignals that involve changes in cell shape, motility or function.
Fernando, H.S., et al. Urol. Oncol. 28(3):320-327(2010)Sossey-Alaoui, K., et al. J. Biol. Chem. 284(48):33019-33029(2009)Sossey-Alaoui, K., et al. J. Biol. Chem. 282(36):26257-26265(2007)Sossey-Alaoui, K., et al. Exp. Cell Res. 308(1):135-145(2005)Sossey-Alaoui, K., et al. J. Biol. Chem. 280(23):21748-21755(2005)
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