|Other Names||Formin-binding protein 1-like, Transducer of Cdc42-dependent actin assembly protein 1, Toca-1, FNBP1L, C1orf39, TOCA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene binds to both CDC42 andN-WASP. This protein promotes CDC42-induced actin polymerization byactivating the N-WASP-WIP complex and, therefore, is involved in apathway that links cell surface signals to the actin cytoskeleton.Alternative splicing results in multiple transcript variantsencoding different isoforms.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Bu, W., et al. PLoS ONE 5 (8), E12153 (2010) :Bu, W., et al. J. Biol. Chem. 284(17):11622-11636(2009)Huett, A., et al. J. Immunol. 182(8):4917-4930(2009)Leung, Y., et al. Cell Host Microbe 3(1):39-47(2008)
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