|Other Names||MAGUK p55 subfamily member 5, MPP5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction. Note=Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membrane (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1 Colocalizes with MPP1 in the retina at the outer limiting membrane (OLM). Localized to the Purkinje cell body and axon|
|Tissue Location||Expressed in the retina (at protein level).|
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Members of the peripheral membrane-associated guanylatekinase (MAGUK) family function in tumor suppression and receptorclustering by forming multiprotein complexes containing distinctsets of transmembrane, cytoskeletal, and cytoplasmic signalingproteins. All MAGUKs contain a PDZ-SH3-GUK core and are dividedinto 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (seeTJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like(see CASK; MIM 300172), based on their size and the presence ofadditional domains (Tseng et al., 2001 [PubMed 11311936]). MPP5 isa member of the p55-like MAGUK subfamily.
Duning, K., et al. J. Biol. Chem. 285(44):33584-33588(2010)Ozcelik, M., et al. J. Neurosci. 30(11):4120-4131(2010)Gosens, I., et al. Exp. Cell Res. 313(19):3959-3970(2007)Gosens, I., et al. Hum. Mol. Genet. 16(16):1993-2003(2007)Wells, C.D., et al. Cell 125(3):535-548(2006)
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