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DIAPH3 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NSV4
Clone Names 100324106
Peptide ID 100324106
Additional Information
Gene ID 81624
Other Names Protein diaphanous homolog 3, Diaphanous-related formin-3, DRF3, MDia2, DIAPH3, DIAP3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DIAPH3
Synonyms DIAP3
Function Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity).
Cellular Location Cytoplasm, cytosol Note=During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis
Research Areas
Citations (0)

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Background

DIAPH3 binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity).

References

DeWard, A.D., et al. J. Biol. Chem. 284(30):20061-20069(2009)Block, J., et al. J Microsc 231(3):506-517(2008)Beli, P., et al. Nat. Cell Biol. 10(7):849-857(2008)Yang, C., et al. PLoS Biol. 5 (11), E317 (2007) :Gupton, S.L., et al. J. Cell. Sci. 120 (PT 19), 3475-3487 (2007) :

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$ 80.00
Cat# BP16587b
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