|Other Names||Thymus-specific serine protease, 34--, Serine protease 16, PRSS16, TSSP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protease that may play a role in T-cell development.|
|Cellular Location||Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal|
|Tissue Location||Expressed predominantly in cortical thymic epithelial cells|
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This gene encodes a serine protease expressed exclusivelyin the thymus. It is thought to play a role in the alternativeantigen presenting pathway used by cortical thymic epithelial cellsduring the positive selection of T cells. The gene is found in thelarge histone gene cluster on chromosome 6, near the majorhistocompatibility complex (MHC) class I region. A secondtranscript variant has been described, but its full length naturehas not been determined.
Shi, J., et al. Nature 460(7256):753-757(2009)Stefansson, H., et al. Nature 460(7256):744-747(2009)Viken, M.K., et al. Genes Immun. 10(4):323-333(2009)Lie, B.A., et al. Hum. Immunol. 68(7):592-598(2007)Luther, C., et al. Genes Immun. 6(1):1-7(2005)
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