|Other Names||Homeobox protein Nkx-61, Homeobox protein NK-6 homolog A, NKX6-1, NKX6A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).|
|Tissue Location||Pancreatic beta cells.|
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Provided below are standard protocols that you may find useful for product applications.
In the pancreas, NKX6.1 is required for the development ofbeta cells and is a potent bifunctional transcription regulatorthat binds to AT-rich sequences within the promoter region oftarget genes Iype et al. (2004) [PubMed 15056733].[supplied byOMIM].
Donelan, W., et al. J. Biol. Chem. 285(16):12181-12189(2010)Zhu, S., et al. Dig. Dis. Sci. 54(5):996-1002(2009)Schisler, J.C., et al. Mol. Cell. Biol. 28(10):3465-3476(2008)Yokoi, N., et al. Diabetes 55(8):2379-2386(2006)Hori, Y., et al. PLoS Med. 2 (4), E103 (2005) :
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