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RIMS1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86UR5 |
|---|---|
| Clone Names | 100318109 |
| Gene ID | 22999 |
|---|---|
| Other Names | Regulating synaptic membrane exocytosis protein 1, Rab-3-interacting molecule 1, RIM 1, Rab-3-interacting protein 2, RIMS1, KIAA0340, RAB3IP2, RIM1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RIMS1 |
|---|---|
| Synonyms | KIAA0340, RAB3IP2, RIM1 |
| Function | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
| Cellular Location | Cell membrane; Peripheral membrane protein. Synapse. Presynaptic cell membrane; Peripheral membrane protein |
| Tissue Location | Expressed in melanocytes (PubMed:23999003). Detected in brain and retina (PubMed:23999003) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a RAS gene superfamilymember that regulates synaptic vesicle exocytosis. The encodedprotein may be part of the protein scaffold of the cell. Defects inthis gene are a cause of cone-rod dystrophy type 7 (CORD7). Severaltranscript variants encoding different isoforms have been found forthis gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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