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EPB49 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q08495
Clone Names 100528282
Peptide ID 100528282
Additional Information
Gene ID 2039
Other Names Dematin, Dematin actin-binding protein, Erythrocyte membrane protein band 49, DMTN, DMT, EPB49
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DMT, EPB49
Function Membrane-cytoskeleton-associated protein with F-actin- binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
Cellular Location Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane. Membrane. Endomembrane system. Cell projection. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuole in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum development
Tissue Location Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney
Research Areas
Citations (0)

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Dematin, or EPB49, is an actin-bundling protein originallyidentified in the erythroid membrane skeleton. Its actin-bundlingactivity is abolished upon phosphorylation by cAMP-dependentprotein kinase and is restored after dephosphorylation (Rana etal., 1993 [PubMed 8341682]).


Vugmeyster, L., et al. J. Biomol. NMR 47(2):155-162(2010)Chen, L., et al. Protein Sci. 18(3):629-636(2009)Vugmeyster, L., et al. J. Biomol. NMR 43(1):39-50(2009)Vermeulen, W., et al. J. Mol. Biol. 359(5):1277-1292(2006)Frank, B.S., et al. J. Biol. Chem. 279(9):7909-7916(2004)

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$ 80.00
Cat# BP16598c
Availability: In Stock
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