SDCBP2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H190 |
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Clone Names | 100603106 |
Gene ID | 27111 |
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Other Names | Syntenin-2, Syndecan-binding protein 2, SDCBP2, SITAC18 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SDCBP2 (HGNC:15756) |
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Synonyms | SITAC18 |
Function | Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). |
Cellular Location | Cytoplasm. Nucleus, nucleolus Nucleus, nucleoplasm. Cell membrane. Nucleus speckle. Note=Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061). |
Tissue Location | Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Syntenin 2 binds to the cytoplasmic domains of the syndecans: it contains a tandem repeat of PDZ domains that reacts with the FYA (phe-tyr-ala) C-terminal amino acid sequence of the syndecans. Cells that overexpress the fusion protein show numerous cell surface extensions, suggesting that Syntenin 2 may have an effect on cytoskeleton-membrane organization. Therefore, Syntenin 2 may function as an adaptor that couples syndecans to cytoskeletal proteins or cytosolic downstream signal-effectors.
References
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Deloukas, P., et al. Nature 414(6866):865-871(2001)Koroll, M., et al. J. Biol. Chem. 276(14):10646-10654(2001)Borrell-Pages, M., et al. Mol. Biol. Cell 11(12):4217-4225(2000)
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