C9orf11 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NQ60 |
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Clone Names | 100422175 |
Gene ID | 54586 |
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Other Names | Equatorin, Acrosome formation-associated factor, EQTN, AFAF, C9orf11 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | EQTN |
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Synonyms | AFAF, C9orf11 |
Function | Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. |
Cellular Location | Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane; Single-pass type I membrane protein. Note=In the anterior acrosome region, enriched on the inner acrosomal membrane but minimal on the outer acrosomal membrane; in contrast in the posterior acrosome region enriched on both the inner and outer acrosomal membranes. |
Tissue Location | Isoform 1 is highly expressed in testis. Isoform 2 is expressed at low levels in skin and blood |
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Provided below are standard protocols that you may find useful for product applications.
Background
AFAF is involved in acrosome biogenesis (By similarity).
References
Laaksovirta, H., et al. Lancet Neurol 9(10):978-985(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Li, Y.C., et al. FEBS Lett. 580(17):4266-4273(2006)Ruiz, A., et al. Biochim. Biophys. Acta 1517(1):128-134(2000)
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