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SRP54 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P61011
Clone Names 100528323
Additional Information
Gene ID 6729
Other Names Signal recognition particle 54 kDa protein, SRP54, SRP54
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SRP54 (HGNC:11301)
Function Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (PubMed:34020957). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538, PubMed:29914977).
Cellular Location Nucleus speckle. Cytoplasm Endoplasmic reticulum
Research Areas
Citations (0)
citation

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Background

SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :Yoshida, M., et al. Mol. Pharmacol. 73(3):987-994(2008)Sakashita, E., et al. Mol. Cell. Biol. 24(3):1174-1187(2004)Kuglstatter, A., et al. Nat. Struct. Biol. 9(10):740-744(2002)Yin, J., et al. RNA 7(10):1389-1396(2001)

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$ 277.78
Cat# BP16615b
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