|Other Names||E3 ubiquitin-protein ligase MARCH7, 632-, Axotrophin, Membrane-associated RING finger protein 7, Membrane-associated RING-CH protein VII, MARCH-VII, RING finger protein 177, MARCH7, AXOT, RNF177|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.|
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Provided below are standard protocols that you may find useful for product applications.
MARCH7 is a member of the MARCH family of membrane-boundE3 ubiquitin ligases (EC 22.214.171.124). MARCH proteins add ubiquitin(see MIM 191339) to target lysines in substrate proteins, therebysignaling their vesicular transport between membrane compartments(Bartee et al., 2004 [PubMed 14722266]).
Szigyarto, C.A., et al. J. Histochem. Cytochem. 58(4):301-308(2010)Nathan, J.A., et al. Traffic 9(7):1130-1145(2008)Muthukumarana, P.A., et al. Int. Immunopharmacol. 6 (13-14), 1993-2001 (2006) :Flierman, D., et al. Proc. Natl. Acad. Sci. U.S.A. 103(31):11589-11594(2006)Lim, J., et al. Cell 125(4):801-814(2006)
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