|Other Names||Snurportin-1, RNA U transporter 1, SNUPN, RNUT1, SPN1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.|
|Cellular Location||Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920). It is re-exported to the cytoplasm by the XPO1- dependent nuclear export receptor pathway (PubMed:10209022)|
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The nuclear import of the spliceosomal snRNPs U1, U2, U4and U5, is dependent on the presence of a complex nuclearlocalization signal. The latter is composed of the5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the UsnRNA and the Sm core domain. The protein encoded by this geneinteracts specifically with m3G-cap and functions as ansnRNP-specific nuclear import receptor. Alternatively splicedtranscript variants encoding the same protein have been identifiedfor this gene.
Goette, M., et al. Biophys. J. 97(2):581-589(2009)Monecke, T., et al. Science 324(5930):1087-1091(2009)Ospina, J.K., et al. Mol. Biol. Cell 16(10):4660-4671(2005)Stelzl, U., et al. Cell 122(6):957-968(2005)Strasser, A., et al. EMBO J. 24(13):2235-2243(2005)
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