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SNUPN Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95149 |
|---|---|
| Clone Names | 100603009 |
| Gene ID | 10073 |
|---|---|
| Other Names | Snurportin-1, RNA U transporter 1, SNUPN, RNUT1, SPN1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SNUPN |
|---|---|
| Synonyms | RNUT1, SPN1 |
| Function | Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. |
| Cellular Location | Nucleus. Cytoplasm Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920). It is re-exported to the cytoplasm by the XPO1- dependent nuclear export receptor pathway (PubMed:10209022) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The nuclear import of the spliceosomal snRNPs U1, U2, U4and U5, is dependent on the presence of a complex nuclearlocalization signal. The latter is composed of the5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the UsnRNA and the Sm core domain. The protein encoded by this geneinteracts specifically with m3G-cap and functions as ansnRNP-specific nuclear import receptor. Alternatively splicedtranscript variants encoding the same protein have been identifiedfor this gene.
References
Goette, M., et al. Biophys. J. 97(2):581-589(2009)Monecke, T., et al. Science 324(5930):1087-1091(2009)Ospina, J.K., et al. Mol. Biol. Cell 16(10):4660-4671(2005)Stelzl, U., et al. Cell 122(6):957-968(2005)Strasser, A., et al. EMBO J. 24(13):2235-2243(2005)
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