|Other Names||Chromodomain Y-like protein, CDY-like, CDYL, CDYL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4.|
|Tissue Location||Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2 is the most abundantly expressed isoform.|
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Chromodomain Y is a primate-specific Y-chromosomal genefamily expressed exclusively in the testis and implicated ininfertility. Although the Y-linked genes are testis-specific, thisautosomal gene is ubiquitously expressed. The Y-linked genes aroseby retrotransposition of an mRNA from this gene, followed byamplification of the retroposed gene. Proteins encoded by this genesuperfamily possess a chromodomain, a motif implicated in chromatinbinding and gene suppression, and a catalytic domain believed to beinvolved in histone acetylation. Multiple proteins are encoded bytranscript variants of this gene.
Franz, H., et al. J. Biol. Chem. 284(50):35049-35059(2009)Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :Mulligan, P., et al. Mol. Cell 32(5):718-726(2008)Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)Caron, C., et al. EMBO Rep. 4(9):877-882(2003)
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