|Other Names||RING1 and YY1-binding protein, Apoptin-associating protein 1, APAP-1, Death effector domain-associated factor, DED-associated factor, YY1 and E4TF1-associated factor 1, RYBP, DEDAF, YEAF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.|
|Cellular Location||Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity).|
|Tissue Location||Widely expressed with highest levels in lymphoid tissues and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
RYBP may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Chen, D., et al. EMBO Rep. 10(2):166-172(2009)Novak, R.L., et al. Cancer Gene Ther. 15(11):713-722(2008)Danen-van Oorschot, A.A., et al. Cell Death Differ. 11(5):564-573(2004)Guelen, L., et al. Oncogene 23(5):1153-1165(2004)
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