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RYBP Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N488
Clone Names 100528285
Additional Information
Gene ID 23429
Other Names RING1 and YY1-binding protein, Apoptin-associating protein 1, APAP-1, Death effector domain-associated factor, DED-associated factor, YY1 and E4TF1-associated factor 1, RYBP, DEDAF, YEAF1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RYBP
Synonyms DEDAF, YEAF1
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911).
Cellular Location Nucleus. Cytoplasm. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8CCI5}. Note=Primarily found in the nucleus Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). {ECO:0000250|UniProtKB:Q8CCI5}
Tissue Location Down-regulated in breast cancer tissues and in several breast cancer cell lines (at protein level) (PubMed:27748911) Widely expressed with highest levels in lymphoid tissues and placenta
Research Areas
Citations (0)
citation

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Background

RYBP may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :Chen, D., et al. EMBO Rep. 10(2):166-172(2009)Novak, R.L., et al. Cancer Gene Ther. 15(11):713-722(2008)Danen-van Oorschot, A.A., et al. Cell Death Differ. 11(5):564-573(2004)Guelen, L., et al. Oncogene 23(5):1153-1165(2004)

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$ 277.78
Cat# BP16629a
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