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CPEB1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BZB8
Clone Names 100528307
Peptide ID 100528307
Additional Information
Gene ID 64506
Other Names Cytoplasmic polyadenylation element-binding protein 1, CPE-BP1, CPE-binding protein 1, h-CEBP, hCPEB-1, CPEB1, CPEB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPEB1
Synonyms CPEB
Function Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU- 3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.
Cellular Location Cytoplasm, P-body. Cytoplasmic granule. Cell junction, synapse. Membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Note=Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity). Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity) Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity) Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity).
Tissue Location Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines
Research Areas
Citations (0)

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This gene encodes a member of the cytoplasmicpolyadenylation element (CPE) binding protein family. This highlyconserved protein binds to a specific RNA sequence called the CPEfound in the 3' UTR of some mRNAs. Similar proteins in Xenopus andmouse function to induce cytoplasmic polyadenylation of dormantmRNAs with short polyA tails, resulting in their translation.Members of this protein family regulate translation of cyclin B1during embryonic cell divisions. Multiple transcript variantsencoding different isoforms have been found for this gene.


Glahder, J.A., et al. Virus Res. 149(2):217-223(2010)Crowther-Swanepoel, D., et al. Nat. Genet. 42(2):132-136(2010)Hansen, C.N., et al. APMIS 117(1):53-59(2009)Ernoult-Lange, M., et al. Mol. Biol. Cell 20(1):176-187(2009)Burns, D.M., et al. Genes Dev. 22(24):3449-3460(2008)

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$ 80.00
Cat# BP16631b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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