|Other Names||Cytoplasmic polyadenylation element-binding protein 1, CPE-BP1, CPE-binding protein 1, h-CEBP, hCPEB-1, CPEB1, CPEB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU- 3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.|
|Cellular Location||Cytoplasm, P-body. Cytoplasmic granule. Cell junction, synapse. Membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Note=Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity). Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity) Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity) Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity).|
|Tissue Location||Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines|
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This gene encodes a member of the cytoplasmicpolyadenylation element (CPE) binding protein family. This highlyconserved protein binds to a specific RNA sequence called the CPEfound in the 3' UTR of some mRNAs. Similar proteins in Xenopus andmouse function to induce cytoplasmic polyadenylation of dormantmRNAs with short polyA tails, resulting in their translation.Members of this protein family regulate translation of cyclin B1during embryonic cell divisions. Multiple transcript variantsencoding different isoforms have been found for this gene.
Glahder, J.A., et al. Virus Res. 149(2):217-223(2010)Crowther-Swanepoel, D., et al. Nat. Genet. 42(2):132-136(2010)Hansen, C.N., et al. APMIS 117(1):53-59(2009)Ernoult-Lange, M., et al. Mol. Biol. Cell 20(1):176-187(2009)Burns, D.M., et al. Genes Dev. 22(24):3449-3460(2008)
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