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RNF34 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q969K3
Clone Names 100603034
Peptide ID 100603034
Additional Information
Gene ID 80196
Other Names E3 ubiquitin-protein ligase RNF34, 632- {ECO:0000269|PubMed:25012219, ECO:0000269|Ref13}, Caspase regulator CARP1, Caspases-8 and -10-associated RING finger protein 1, CARP-1, FYVE-RING finger protein Momo, RNF34 (HGNC:17297)
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF34 (HGNC:17297)
Function E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).
Cellular Location Cell membrane; Peripheral membrane protein. Endomembrane system {ECO:0000250|UniProtKB:Q6AYH3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6AYH3}. Nucleus. Nucleus speckle. Cytoplasm, cytosol
Tissue Location Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
Research Areas
Citations (0)

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The protein encoded by this gene contains a RINF finger, amotif known to be involved in protein-protein and protein-DNAinteractions. This protein interacts with DNAJA3/hTid-1, which is aDnaJ protein reported to function as a modulator of apoptosis.Overexpression of this gene in Hela cells was shown to confer theresistance to TNF-alpha induced apoptosis, suggesting ananti-apoptotic function of this protein. This protein can becleaved by caspase-3 during the induction of apoptosis.Alternatively spliced transcript variants encoding distinctisoforms have been reported.


Erlbruch, A., et al. Proteomics 10(16):2890-2900(2010)Yang, W., et al. Cell Cycle 7(5):670-682(2008)Yang, W., et al. J. Biol. Chem. 282(5):3273-3281(2007)Konishi, T., et al. Mol. Cancer Ther. 4(5):743-750(2005)Sasaki, S., et al. J. Exp. Clin. Cancer Res. 23(3):507-512(2004)

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$ 80.00
Cat# BP16633b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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