|Other Names||Signal-regulatory protein gamma, SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-b2, SIRP-beta-2, CD172g, SIRPG, SIRPB2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thesignal-regulatory protein (SIRP) family, and also belongs to theimmunoglobulin superfamily. SIRP family members are receptor-typetransmembrane glycoproteins known to be involved in the negativeregulation of receptor tyrosine kinase-coupled signaling processes.Alternatively spliced transcript variants encoding differentisoforms have been described.
Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)Kawasaki, M., et al. Clin. Exp. Rheumatol. 27(2):260-266(2009)Stefanidakis, M., et al. Blood 112(4):1280-1289(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Barclay, A.N., et al. Nat. Rev. Immunol. 6(6):457-464(2006)
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