|Other Names||Cohesin subunit SA-1, SCC3 homolog 1, Stromal antigen 1, STAG1, SA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.|
|Cellular Location||Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation|
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This gene is a member of the SCC3 family and is expressedin the nucleus. It encodes a component of cohesin, a multisubunitprotein complex that provides sister chromatid cohesion along thelength of a chromosome from DNA replication through prophase andprometaphase, after which it is dissociated in preparation forsegregation during anaphase.
Chasman, D.I., et al. PLoS Genet. 5 (11), E1000730 (2009) :Canudas, S., et al. J. Cell Biol. 187(2):165-173(2009)Rubio, E.D., et al. Proc. Natl. Acad. Sci. U.S.A. 105(24):8309-8314(2008)Watrin, E., et al. Curr. Biol. 16(9):863-874(2006)Losada, A., et al. J. Cell. Sci. 118 (PT 10), 2133-2141 (2005) :
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