|Other Names||Group XIIA secretory phospholipase A2, GXII sPLA2, sPLA2-XII, Phosphatidylcholine 2-acylhydrolase 12A, PLA2G12A, PLA2G12|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine.|
|Cellular Location||Secreted. Cytoplasm|
|Tissue Location||Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Secreted phospholipase A2 (sPLA2) enzymes liberatearachidonic acid from phospholipids for production of eicosanoidsand exert a variety of physiologic and pathologic effects. GroupXII sPLA2s, such as PLA2G12A, have relatively low specific activityand are structurally and functionally distinct from other sPLA2s(Gelb et al., 2000 [PubMed 11031251]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Chen, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7401-7406(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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