|Other Names||RB-associated KRAB zinc finger protein, RB-associated KRAB repressor, hRBaK, Zinc finger protein 769, RBAK, ZNF769|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May repress E2F-dependent transcription. May promote AR- dependent transcription.|
|Tissue Location||Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.|
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This gene encodes a nuclear protein which interacts withthe tumor suppressor retinoblastoma 1. The two interacting proteinsare thought to act as a transcriptional repressor for promoterswhich are activated by the E2F1 transcription factor. This proteincontains a Kruppel-associated box (KRAB), which is atranscriptional repressor motif.
Trynka, G., et al. Gut 58(8):1078-1083(2009)Ma, Y., et al. BMC Genomics 10, 109 (2009) :Jeske, Y.W., et al. Clin. Exp. Pharmacol. Physiol. 35(4):380-385(2008)So, A., et al. Clin. Endocrinol. (Oxf) 65(6):829-831(2006)Vertegaal, A.C., et al. Mol. Cell Proteomics 5(12):2298-2310(2006)
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