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SULT1B1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43704 |
|---|---|
| Clone Names | 100617082 |
| Gene ID | 27284 |
|---|---|
| Other Names | Sulfotransferase family cytosolic 1B member 1, ST1B1, Sulfotransferase 1B1, 282-, Sulfotransferase 1B2, ST1B2, Thyroid hormone sulfotransferase, SULT1B1, ST1B2, SULT1B2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SULT1B1 |
|---|---|
| Synonyms | ST1B2 {ECO:0000303|PubMed:9443824}, SULT |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine- derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440). |
| Cellular Location | Cytoplasm |
| Tissue Location | Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sulfotransferase enzymes catalyze the sulfate conjugationof many hormones, neurotransmitters, drugs, and xenobioticcompounds. These cytosolic enzymes are different in their tissuedistributions and substrate specificities. The gene structure(number and length of exons) is similar among family members.However, the total genomic length of this gene is greater than thatof other SULT1 genes.
References
Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Allali-Hassani, A., et al. PLoS Biol. 5 (5), E97 (2007) :Dombrovski, L., et al. Proteins 64(4):1091-1094(2006)Meinl, W., et al. Biochem. Biophys. Res. Commun. 288(4):855-862(2001)
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