|Other Names||Sulfotransferase family cytosolic 1B member 1, ST1B1, Sulfotransferase 1B1, 282-, Sulfotransferase 1B2, ST1B2, Thyroid hormone sulfotransferase, SULT1B1, ST1B2, SULT1B2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.|
|Tissue Location||Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
Sulfotransferase enzymes catalyze the sulfate conjugationof many hormones, neurotransmitters, drugs, and xenobioticcompounds. These cytosolic enzymes are different in their tissuedistributions and substrate specificities. The gene structure(number and length of exons) is similar among family members.However, the total genomic length of this gene is greater than thatof other SULT1 genes.
Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Allali-Hassani, A., et al. PLoS Biol. 5 (5), E97 (2007) :Dombrovski, L., et al. Proteins 64(4):1091-1094(2006)Meinl, W., et al. Biochem. Biophys. Res. Commun. 288(4):855-862(2001)
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