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SIGLEC5 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O15389
Clone Names 100617107
Peptide ID 100617107
Additional Information
Gene ID 8778
Other Names Sialic acid-binding Ig-like lectin 5, Siglec-5, CD33 antigen-like 2, Obesity-binding protein 2, OB-BP2, OB-binding protein 2, CD170, SIGLEC5, CD33L2, OBBP2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD33L2, OBBP2
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation
Research Areas
Citations (0)

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The sialic acid-binding immunoglobulin-like lectins(SIGLECs), such as SIGLEC5, are a subgroup of the immunoglobulin(Ig) superfamily that mediate protein-carbohydrate interactions.They specifically interact with sialic acids in glycoproteins andglycolipids, with each SIGLEC having a particular preference forboth the nature of the sialic acid and its glycosidic linkage toadjacent sugars. SIGLECs have similar structures, includingextracellular Ig-like domains composed of an N-terminal V-setdomain followed by varying numbers of C2-set domains. It appearsthat all SIGLECs have an unusual arrangement of conserved cysteineresidues in the V-set and adjacent C2-set domains. Most SIGLECs areexpressed uniquely within the hematopoietic system (Cornish et al.,1998 [PubMed 9731071]).


Soto, P.C., et al. J. Immunol. 184(8):4185-4195(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Carlin, A.F., et al. J. Exp. Med. 206(8):1691-1699(2009)Zhuravleva, M.A., et al. J. Mol. Biol. 375(2):437-447(2008)Gunnarsson, P., et al. FASEB J. 21(14):4059-4069(2007)

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$ 80.00
Cat# BP16649a
Availability: In Stock
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