|Other Names||Unconventional myosin-Ie, Myosin-Ic, Unconventional myosin 1E, MYO1E, MYO1C|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle Cell junction. Note=Colocalizes with F-actin (By similarity). In cultured podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with cytoplasmic vesicles, including endocytic clathrin-coated vesicles. Colocalizes with dynamin at cytoplasmic vesicles.|
|Tissue Location||Expressed in the immune system. In the kidney, predominantly expressed in the glomerulus, including podocytes|
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Provided below are standard protocols that you may find useful for product applications.
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
Feeser, E.A., et al. Biochemistry 49(43):9353-9360(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Krendel, M., et al. FEBS Lett. 581(4):644-650(2007)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)El Mezgueldi, M., et al. J. Biol. Chem. 277(24):21514-21521(2002)
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