|Other Names||Deoxycytidylate deaminase, dCMP deaminase, DCTD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Supplies the nucleotide substrate for thymidylate synthetase.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the deaminationof dCMP to dUMP, the nucleotide substrate for thymidylate synthase.The encoded protein is allosterically activated by dCTP andinhibited by dTTP, and is found as a homohexamer. This protein useszinc as a cofactor for its activity. Two transcript variantsencoding different isoforms have been found for this gene.
Tanaka, M., et al. Cancer (2010) In press :Okazaki, T., et al. Clin. Cancer Res. 16(1):320-329(2010)Rha, S.Y., et al. Oncologist 12(6):622-630(2007)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
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