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DCTD Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P32321
Clone Names 100603130
Additional Information
Gene ID 1635
Other Names Deoxycytidylate deaminase, dCMP deaminase, DCTD
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCTD (HGNC:2710)
Function Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS (PubMed:7685356). Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl- dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) (PubMed:33833118). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP) (PubMed:33833118).
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene catalyzes the deaminationof dCMP to dUMP, the nucleotide substrate for thymidylate synthase.The encoded protein is allosterically activated by dCTP andinhibited by dTTP, and is found as a homohexamer. This protein useszinc as a cofactor for its activity. Two transcript variantsencoding different isoforms have been found for this gene.

References

Tanaka, M., et al. Cancer (2010) In press :Okazaki, T., et al. Clin. Cancer Res. 16(1):320-329(2010)Rha, S.Y., et al. Oncologist 12(6):622-630(2007)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)

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$ 277.78
Cat# BP16651a
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