|Other Names||Cell division cycle-associated protein 4, Hematopoietic progenitor protein, CDCA4, HEPP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).|
|Tissue Location||Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.|
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This gene encodes a protein that belongs to the E2F familyof transcription factors. This protein regulates E2F-dependenttranscriptional activation and cell proliferation, mainly throughthe E2F/retinoblastoma protein pathway. It also functions in theregulaton of JUN oncogene expression. This protein showsdistinctive nuclear-mitotic apparatus distribution, it is involvedin spindle organization from prometaphase, and may also play a roleas a midzone factor involved in chromosome segregation orcytokinesis. Two alternatively spliced transcript variants encodingthe same protein have been noted for this gene. Two pseudogeneshave also been identified on chromosome 1.
Tategu, M., et al. Biochimie 90(10):1515-1522(2008)Wang, L., et al. Cell Motil. Cytoskeleton 65(7):581-593(2008)Hayashi, R., et al. J. Biol. Chem. 281(47):35633-35648(2006)Walker, M.G. Curr Cancer Drug Targets 1(1):73-83(2001)Abdullah, J.M., et al. Blood Cells Mol. Dis. 27(3):667-676(2001)
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