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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   TNIP2 Antibody (Center) Blocking Peptide   

TNIP2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8NFZ5
Clone Names 100712020
Peptide ID 100712020
Additional Information
Gene ID 79155
Other Names TNFAIP3-interacting protein 2, A20-binding inhibitor of NF-kappa-B activation 2, ABIN-2, Fetal liver LKB1-interacting protein, TNIP2 {ECO:0000312|EMBL:EAW825141}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNIP2 {ECO:0000312|EMBL:EAW82514.1}
Function Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Cellular Location Cytoplasm. Nucleus
Tissue Location Ubiquitously expressed in all tissues examined.
Research Areas
Citations (0)

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TNIP2 binds to the C-terminal zinc finger domain of A20(TNFAIP3; MIM 191163) and is involved in activation of the ERK (seeMAPK3; MIM 601795) MAP kinase pathway in various cell types (VanHuffel et al., 2001 [PubMed 11390377]; Papoutsopoulou et al., 2006[PubMed 16633345]).


Raychaudhuri, S., et al. Nat. Genet. 41(12):1313-1318(2009)Handoyo, H., et al. Biochem. J. 424(1):109-118(2009)Verstrepen, L., et al. Biochem. Pharmacol. 78(2):105-114(2009)Huang, L., et al. Oncogene 27(47):6131-6140(2008)Liu, Y., et al. J. Radiat. Res. 48(1):13-20(2007)

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$ 80.00
Cat# BP16658c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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