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Mouse Nlrp6 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q91WS2
Clone Names 110726303
Peptide ID 110726303
Additional Information
Gene ID 101613
Other Names NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5-like, Nlrp6, Nalp6, Pypaf5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Nlrp6
Synonyms Nalp6, Navr, Pypaf5
Function As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to yet unidentified signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:21593405). Essential for gut mucosal self- renewal and proliferation (PubMed:21593405, PubMed:21565393, PubMed:21543645). Maintains intestinal homeostasis and a healthy intestinal microbiota (PubMed:21565393, PubMed:22763455). This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells (PubMed:21565393). Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome- dependent, but IL1B- and IL18-independent (PubMed:24581500). During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum (PubMed:22763455). May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (PubMed:26253422).
Cellular Location Isoform 1: Cytoplasm {ECO:0000250|UniProtKB:Q63035}. Inflammasome {ECO:0000250|UniProtKB:P59044}. Cell membrane {ECO:0000250|UniProtKB:Q63035}. Nucleus membrane {ECO:0000250|UniProtKB:Q63035}
Tissue Location Highly expressed in the gastrointestinal tract, predominantly in colonic myofibroblasts and in colonic epithelial and endothelial cells. Within the intestinal mucosa, highly expressed by goblet cells. Also expressed in hepatocytes and in immune cells, including CD4(+) and CD8(+) T-cells, dendritic cells, mastocytes and peritoneal macrophages, as well as in lung, kidney, bladder and gonads.
Research Areas
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Background

Nlrp6 may mediate activation of CASP1 via ASC and promote activation of NF-kappa-B (By similarity).

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$ 80.00
Cat# BP16660b
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