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H2BFWT Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7Z2G1 |
|---|---|
| Clone Names | 110712010 |
| Gene ID | 158983 |
|---|---|
| Other Names | Histone H2B type W-T, H2B histone family member W testis-specific, H2BFWT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | H2BW1 (HGNC:27252) |
|---|---|
| Function | Atypical histone H2B that can form nucleosomes structurally and dynamically indistinguishable from those containing conventional H2B. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (PubMed:15475252, PubMed:16449661). However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes (PubMed:16449661). May be important for telomere function and play a role in spermatogenesis (PubMed:16449661, PubMed:19583817). |
| Cellular Location | Nucleus membrane. Chromosome. Chromosome, telomere |
| Tissue Location | Testis-specific (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Two molecules of each of the four core histones (H2A,H2B, H3, and H4) form an octamer, around which approximately 146 bpof DNA is wrapped in repeating units, called nucleosomes. Thelinker histone, H1, interacts with linker DNA between nucleosomesand functions in the compaction of chromatin into higher orderstructures. This gene encodes a member of the H2B histone familythat is specifically expressed in sperm nuclei. A polymorphism inthe 5' UTR of this gene is associated with male infertility.
References
Lee, J., et al. J. Cell. Mol. Med. 13 (8B), 1942-1951 (2009) :Boulard, M., et al. Mol. Cell. Biol. 26(4):1518-1526(2006)Churikov, D., et al. Genomics 84(4):745-756(2004)Churikov, D., et al. Cytogenet. Genome Res. 105 (2-4), 203-214 (2004) :
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