|Other Names||Histone H2B type W-T, H2B histone family member W testis-specific, H2BFWT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.|
|Cellular Location||Nucleus membrane. Chromosome|
|Tissue Location||Testis-specific. Present in sperm cells (at protein level).|
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Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Two molecules of each of the four core histones (H2A,H2B, H3, and H4) form an octamer, around which approximately 146 bpof DNA is wrapped in repeating units, called nucleosomes. Thelinker histone, H1, interacts with linker DNA between nucleosomesand functions in the compaction of chromatin into higher orderstructures. This gene encodes a member of the H2B histone familythat is specifically expressed in sperm nuclei. A polymorphism inthe 5' UTR of this gene is associated with male infertility.
Lee, J., et al. J. Cell. Mol. Med. 13 (8B), 1942-1951 (2009) :Boulard, M., et al. Mol. Cell. Biol. 26(4):1518-1526(2006)Churikov, D., et al. Genomics 84(4):745-756(2004)Churikov, D., et al. Cytogenet. Genome Res. 105 (2-4), 203-214 (2004) :
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