|Other Names||3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase, AKR1D1, SRD5B1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates.|
|Tissue Location||Highly expressed in liver. Expressed in testis and weakly in colon.|
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The enzyme encoded by this gene is responsible for thecatalysis of the 5-beta-reduction of bile acid intermediates andsteroid hormones carrying a delta(4)-3-one structure. Deficiency ofthis enzyme may contribute to hepatic dysfunction. Three transcriptvariants encoding different isoforms have been found for this gene.Other variants may be present, but their full-length natures havenot been determined yet.
Steen, N.E., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :Drury, J.E., et al. J. Biol. Chem. 285(32):24529-24537(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ueki, I., et al. J. Gastroenterol. Hepatol. 24(5):776-785(2009)Panagopoulos, I., et al. Oncol. Rep. 21(3):615-624(2009)
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