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AKR1D1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P51857 |
|---|---|
| Clone Names | 110617053 |
| Gene ID | 6718 |
|---|---|
| Other Names | 3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase, AKR1D1, SRD5B1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AKR1D1 |
|---|---|
| Synonyms | SRD5B1 |
| Function | Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in liver. Expressed in testis and weakly in colon. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The enzyme encoded by this gene is responsible for thecatalysis of the 5-beta-reduction of bile acid intermediates andsteroid hormones carrying a delta(4)-3-one structure. Deficiency ofthis enzyme may contribute to hepatic dysfunction. Three transcriptvariants encoding different isoforms have been found for this gene.Other variants may be present, but their full-length natures havenot been determined yet.
References
Steen, N.E., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :Drury, J.E., et al. J. Biol. Chem. 285(32):24529-24537(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ueki, I., et al. J. Gastroenterol. Hepatol. 24(5):776-785(2009)Panagopoulos, I., et al. Oncol. Rep. 21(3):615-624(2009)
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