|Other Names||Potassium voltage-gated channel subfamily C member 4, KSHIIIC, Voltage-gated potassium channel subunit Kv34, KCNC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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The Shaker gene family of Drosophila encodes components ofvoltage-gated potassium channels and is comprised of foursubfamilies. Based on sequence similarity, this gene is similar tothe Shaw subfamily. The protein encoded by this gene belongs to thedelayed rectifier class of channel proteins and is an integralmembrane protein that mediates the voltage-dependent potassium ionpermeability of excitable membranes. It generates atypicalvoltage-dependent transient current that may be important forneuronal excitability. Multiple transcript variants have been foundfor this gene.
Mosing, M.A., et al. Twin Res Hum Genet 13(4):398-403(2010)Menendez, S.T., et al. J. Pathol. 221(4):402-410(2010)Leblanc, N. Cardiovasc. Res. 86(3):351-352(2010)Miguel-Velado, E., et al. Cardiovasc. Res. 86(3):383-391(2010)Abbott, G.W., et al. FASEB J. 20(2):293-301(2006)
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