|Other Names||DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, MHsaIIIA, DNMT3A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.|
|Cellular Location||Nucleus. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin|
|Tissue Location||Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.|
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CpG methylation is an epigenetic modification that isimportant for embryonic development, imprinting, and X-chromosomeinactivation. Studies in mice have demonstrated that DNAmethylation is required for mammalian development. This geneencodes a DNA methyltransferase that is thought to function in denovo methylation, rather than maintenance methylation. The proteinlocalizes to the cytoplasm and nucleus and its expression isdevelopmentally regulated. Alternative splicing results in multipletranscript variants encoding different isoforms. [provided byRefSeq].
Holz-Schietinger, C., et al. J. Biol. Chem. 285(38):29091-29100(2010)Kelemen, L.E., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1822-1830(2010)Park, C.W., et al. J Cardiovasc Transl Res 3(3):290-295(2010)Haggarty, P., et al. PLoS ONE 5 (6), E11329 (2010) :Zhao, Z., et al. J. Biomed. Biotechnol. 2010, 737535 (2010) :
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