|Other Names||Alpha-2, 8-sialyltransferase 8F, 2499-, Sialyltransferase 8F, SIAT8-F, Sialyltransferase St8Sia VI, ST8SiaVI, ST8SIA6, SIAT8F|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc- alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Sialic acid is a key determinate of oligosaccharidestructures involved in cell-cell communication, cell-substrateinteraction, adhesion, and protein targeting. ST8SIA6 belongs to afamily of sialyltransferases (EC 126.96.36.199) that synthesizesialylglycoconjugates (Takashima et al., 2002 [PubMed11980897]).
Yang, J.J., et al. JAMA 301(4):393-403(2009)Avril, T., et al. J. Leukoc. Biol. 80(4):787-796(2006)Harduin-Lepers, A., et al. Glycobiology 15(8):805-817(2005)Deloukas, P., et al. Nature 429(6990):375-381(2004)Takashima, S., et al. J. Biol. Chem. 277(27):24030-24038(2002)
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