|Other Names||Erythropoietin receptor, EPO-R, EPOR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells|
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This gene encodes the erythropoietin receptor which is amember of the cytokine receptor family. Upon erythropoietinbinding, this receptor activates Jak2 tyrosine kinase whichactivates different intracellular pathways including: Ras/MAPkinase, phosphatidylinositol 3-kinase and STAT transcriptionfactors. The stimulated erythropoietin receptor appears to have arole in erythroid cell survival. Defects in the erythropoietinreceptor may produce erythroleukemia and familial erythrocytosis.Dysregulation of this gene may affect the growth of certain tumors.Alternate splicing results in multiple transcript variants.
Lim, A.C., et al. Biochemistry 49(18):3797-3804(2010)Perrotta, S., et al. PLoS ONE 5 (8), E12015 (2010) :Khankin, E.V., et al. PLoS ONE 5 (2), E9246 (2010) :Wincewicz, A., et al. Folia Histochem. Cytobiol. 47(3):425-430(2009)Ketteler, R., et al. J. Biol. Chem. 278(4):2654-2660(2003)
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