|Other Names||Lysophosphatidic acid receptor 4, LPA receptor 4, LPA-4, G-protein coupled receptor 23, P2Y purinoceptor 9, P2Y9, P2Y5-like receptor, Purinergic receptor 9, LPAR4, GPR23, LPA4, P2RY9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR23, LPA4, P2RY9|
|Function||Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the lysophosphatidic acidreceptor family. It may also be related to the P2Y receptors, afamily of receptors that bind purine and pyrimidine nucleotides andare coupled to G proteins. The encoded protein may play a role inmonocytic differentiation.
Liu, Y.B., et al. J. Cell. Biochem. 109(4):794-800(2010)Kumar, S.A., et al. Leuk. Lymphoma 50(12):2038-2048(2009)Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)Dowal, L., et al. J. Biol. Chem. 281(33):23999-24014(2006)Noguchi, K., et al. J. Biol. Chem. 278(28):25600-25606(2003)
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