|Other Names||Probable cation-transporting ATPase 13A2, 363-, ATP13A2, PARK9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity.|
|Cellular Location||Membrane; Multi-pass membrane protein. Lysosome|
|Tissue Location||Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the P5 subfamily of ATPaseswhich transports inorganic cations as well as other substrates.Mutations in this gene are associated with Kufor-Rakeb syndrome(KRS), also referred to as Parkinson disease 9. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Dos Santos, A.V., et al. Neurosci. Lett. 485(2):121-124(2010)Reetz, K., et al. Neurobiol. Dis. 39(3):402-408(2010)Schneider, S.A., et al. Mov. Disord. 25(8):979-984(2010)Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Fei, Q.Z., et al. Neurosci. Lett. 475(2):61-63(2010)
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