|Other Names||Zinc finger and BTB domain-containing protein 38, ZBTB38 (HGNC:26636)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl- CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA- replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).|
|Cellular Location||Nucleus. Chromosome. Note=Localizes to chromocenters.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a zinc fingertranscriptional activator that binds methylated DNA. The encodedprotein can form homodimers or heterodimers through the zinc fingerdomains. In mouse, inhibition of this protein has been associatedwith apoptosis in some cell types.
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Cho, Y.S., et al. Nat. Genet. 41(5):527-534(2009)Soranzo, N., et al. PLoS Genet. 5 (4), E1000445 (2009) :
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