|Other Names||Cyclin-G2, CCNG2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in growth regulation and in negative regulation of cell cycle progession.|
|Tissue Location||High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The eukaryotic cell cycle is governed by cyclin-dependentprotein kinases (CDKs) whose activities are regulated by cyclinsand CDK inhibitors. The 8 species of cyclins reported in mammals,cyclins A through H, share a conserved amino acid sequence of about90 residues called the cyclin box. The amino acid sequence ofcyclin G is well conserved among mammals. The nucleotide sequenceof cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1,cyclin G2 contains a C-terminal PEST protein destabilization motif,suggesting that cyclin G2 expression is tightly regulated throughthe cell cycle.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Choi, M.G., et al. J. Surg. Res. 157(2):168-174(2009)Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)Xu, G., et al. Mol. Biol. Cell 19(11):4968-4979(2008)Kasukabe, T., et al. Cancer Sci. 99(8):1693-1698(2008)
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