CCNG2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q16589 |
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Clone Names | 100603008 |
Gene ID | 901 |
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Other Names | Cyclin-G2, CCNG2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CCNG2 |
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Function | May play a role in growth regulation and in negative regulation of cell cycle progression. |
Cellular Location | Cytoplasm. |
Tissue Location | High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
The eukaryotic cell cycle is governed by cyclin-dependentprotein kinases (CDKs) whose activities are regulated by cyclinsand CDK inhibitors. The 8 species of cyclins reported in mammals,cyclins A through H, share a conserved amino acid sequence of about90 residues called the cyclin box. The amino acid sequence ofcyclin G is well conserved among mammals. The nucleotide sequenceof cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1,cyclin G2 contains a C-terminal PEST protein destabilization motif,suggesting that cyclin G2 expression is tightly regulated throughthe cell cycle.
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Choi, M.G., et al. J. Surg. Res. 157(2):168-174(2009)Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)Xu, G., et al. Mol. Biol. Cell 19(11):4968-4979(2008)Kasukabe, T., et al. Cancer Sci. 99(8):1693-1698(2008)
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