|Other Names||Cyclin-G2, CCNG2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in growth regulation and in negative regulation of cell cycle progession.|
|Tissue Location||High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
The eukaryotic cell cycle is governed by cyclin-dependentprotein kinases (CDKs) whose activities are regulated by cyclinsand CDK inhibitors. The 8 species of cyclins reported in mammals,cyclins A through H, share a conserved amino acid sequence of about90 residues called the cyclin box. The amino acid sequence ofcyclin G is well conserved among mammals. The nucleotide sequenceof cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1,cyclin G2 contains a C-terminal PEST protein destabilization motif,suggesting that cyclin G2 expression is tightly regulated throughthe cell cycle.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Choi, M.G., et al. J. Surg. Res. 157(2):168-174(2009)Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)Xu, G., et al. Mol. Biol. Cell 19(11):4968-4979(2008)Kasukabe, T., et al. Cancer Sci. 99(8):1693-1698(2008)
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