|Other Names||Transforming growth factor-beta-induced protein ig-h3, Beta ig-h3, Kerato-epithelin, RGD-containing collagen-associated protein, RGD-CAP, TGFBI, BIGH3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).|
|Cellular Location||Secreted Secreted, extracellular space, extracellular matrix. Note=May be associated both with microfibrils and with the cell surface (PubMed:8077289)|
|Tissue Location||Highly expressed in the corneal epithelium (PubMed:8077289). Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:8077289)|
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This gene encodes an RGD-containing protein that binds totype I, II and IV collagens. The RGD motif is found in manyextracellular matrix proteins modulating cell adhesion and servesas a ligand recognition sequence for several integrins. Thisprotein plays a role in cell-collagen interactions and may beinvolved in endochondrial bone formation in cartilage. The proteinis induced by transforming growth factor-beta and acts to inhibitcell adhesion. Mutations in this gene are associated with multipletypes of corneal dystrophy.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Edelstein, S.L., et al. Cornea 29(6):698-700(2010)Romero, P., et al. Mol. Vis. 16, 1601-1609 (2010) :Paliwal, P., et al. Mol. Vis. 16, 1429-1438 (2010) :Yang, J., et al. Mol. Vis. 16, 1186-1193 (2010) :
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